HBX 28258

CAS No. 1426544-54-8

HBX 28258 ( HBX28258 )

Catalog No. M11801 CAS No. 1426544-54-8

HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HBX 28258
  • Note
    Research use only, not for human use.
  • Brief Description
    HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM.
  • Description
    HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase.
  • Synonyms
    HBX28258
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1426544-54-8
  • Formula Weight
    436.00
  • Molecular Formula
    C26H30ClN3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC2=C(Cl)C3=C(CCCC3)N=C2C=C1)NCCCN(CC)CC4=CC=CC=C4
  • Chemical Name
    2-Acridinecarboxamide, 9-chloro-N-[3-[ethyl(phenylmethyl)amino]propyl]-5,6,7,8-tetrahydro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.
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